Research output per year
Research output per year
Project Details
Project Description
Antimicrobial drug resistance is a major concern for human health that is not being addressed by
current strategies in the development of antimicrobial agents. Bacteriophages represent a unique
and innovative solution with significant therapeutic potential to manage serious infection with
resistant bacteria. The major limitation is how to effectively and efficiently deliver bacteriophages
to the site of serious infection. This research will for the first time develop and evaluate a novel
formulation to deliver bacteriophages to the respiratory tract, providing proof of principle for
this innovative approach to treating serious life threatening infections which would represent a
major advance in overcoming a major unmet urgent medical need.
current strategies in the development of antimicrobial agents. Bacteriophages represent a unique
and innovative solution with significant therapeutic potential to manage serious infection with
resistant bacteria. The major limitation is how to effectively and efficiently deliver bacteriophages
to the site of serious infection. This research will for the first time develop and evaluate a novel
formulation to deliver bacteriophages to the respiratory tract, providing proof of principle for
this innovative approach to treating serious life threatening infections which would represent a
major advance in overcoming a major unmet urgent medical need.
| Status | Finished |
|---|---|
| Effective start/end date | 2/01/18 → 31/12/21 |
Funding
- National Health and Medical Research Council (NHMRC) (Australia): A$563,620.90
Research output
- 7 Article
-
The effects of different doses of inhaled bacteriophage therapy for Pseudomonas aeruginosa pulmonary infections in mice
Chang, R. Y. K., Chow, M. Y. T., Wang, Y., Liu, C., Hong, Q., Morales, S., McLachlan, A. J., Kutter, E., Li, J. & Chan, H. K., Jul 2022, In: Clinical Microbiology and Infection. 28, 7, p. 983-989 7 p.Research output: Contribution to journal › Article › Research › peer-review
16 Citations (Scopus) -
Synergistic activity of phage PEV20-ciprofloxacin combination powder formulation—A proof-of-principle study in a P. aeruginosa lung infection model
Lin, Y., Quan, D., Chang, R. Y. K., Chow, M. Y. T., Wang, Y., Li, M., Morales, S., Britton, W. J., Kutter, E., Li, J. & Chan, H-K., Jan 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 158, p. 166-171 6 p.Research output: Contribution to journal › Article › Research › peer-review
39 Citations (Scopus) -
Inhalable bacteriophage powders: Glass transition temperature and bioactivity stabilization
Chang, R. Y. K., Kwok, P. C. L., Khanal, D., Morales, S., Kutter, E., Li, J. & Chan, H. K., May 2020, In: Bioengineering & Translational Medicine. 5, 2, 10 p., e10159.Research output: Contribution to journal › Article › Research › peer-review
Open Access38 Citations (Scopus)
Equipment
-
Animal Research Platform (MARP)
Christine Findlay (Manager)
Faculty of Medicine Nursing and Health Sciences Research PlatformsFacility/equipment: Facility
-
Australian Synchrotron
Office of the Vice-Provost (Research and Research Infrastructure)Facility/equipment: Facility
-
MASSIVE
Slava Kitaeff (Manager) & David Powell (Manager)
Office of the Vice-Provost (Research and Research Infrastructure)Facility/equipment: Facility