| Status | Finished |
|---|---|
| Effective start/end date | 1/01/06 → 31/12/18 |
Funding
- National Health & Medical Research Council (NHMRC): AUD727,610.00
- National Health & Medical Research Council (NHMRC)
- National Health & Medical Research Council (NHMRC): AUD474,250.00
- National Health & Medical Research Council (NHMRC): AUD203,250.00
- National Health & Medical Research Council (NHMRC): AUD428,250.00
- National Health & Medical Research Council (NHMRC)
Related content
Research Output
Development of a highly selective allosteric antagonist radioligand for the type 1 cholecystokinin receptor and elucidation of its molecular basis of binding
Research output: Contribution to journal › Article › Research › peer-review
Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics
Research output: Contribution to journal › Article › Research › peer-review
Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor
Research output: Contribution to journal › Article › Research › peer-review
Prediction of loops in G protein-coupled receptor homology models: effect of imprecise surroundings and constraints
Research output: Contribution to journal › Article › Research › peer-review
Detection and quantification of allosteric modulation of endogenous M4 muscarinic acetylcholine receptor using impedance-based label-free technology in a neuronal cell line
Research output: Contribution to journal › Article › Research › peer-review
Novel allosteric modulators of G protein-coupled receptors
Research output: Contribution to journal › Article › Research › peer-review
Biased agonism and biased allosteric modulation at the CB1 cannabinoid receptors
Research output: Contribution to journal › Article › Research › peer-review
Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor
Research output: Contribution to journal › Article › Research › peer-review
Synthesis and pharmacological evaluation of M4 muscarinic receptor positive allosteric modulators derived from VU10004
Research output: Contribution to journal › Article › Research › peer-review
Differential impact of amino acid substitutions on critical residues of the human glucagon-like peptide-1 receptor involved in peptide activity and small-molecule allosterys
Research output: Contribution to journal › Article › Research › peer-review
4-phenylpyridin-2-one derivatives: a novel class of positive allosteric modulator of the M1 muscarinic acetylcholine receptor
Research output: Contribution to journal › Article › Research › peer-review
Phase-plate cryo-EM structure of a class B GPCR-G-protein complex
Research output: Contribution to journal › Article › Research › peer-review
Extracellular loop 2 of the adenosine A1 receptor has a key role in orthosteric ligand affinity and agonist efficacy
Research output: Contribution to journal › Article › Research › peer-review
Calcitonin
Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review
Endogenous allosteric modulators of G protein-coupled receptors
Research output: Contribution to journal › Article › Research › peer-review
Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor
Research output: Contribution to journal › Article › Research › peer-review
A structure-activity relationship study of the positive allosteric modulator LY2033298 at the M4 muscarinic acetylcholine receptor
Research output: Contribution to journal › Article › Research › peer-review
A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal dengue virus infection
Research output: Contribution to journal › Article › Research › peer-review
Molecular mechanism of action of triazolobenzodiazepinone agonists of the type 1 cholecystokinin receptor. Possible cooperativity across the receptor homodimeric complex
Research output: Contribution to journal › Article › Research › peer-review
Ligand-dependent modulation of G protein conformation alters drug efficacy
Research output: Contribution to journal › Article › Research › peer-review
Role of the second extracellular loop of the adenosine A1 receptor on allosteric modulator binding, signaling, and cooperativity
Research output: Contribution to journal › Article › Research › peer-review
Biased agonism of endogenous opioid peptides at the μ-opioid receptor
Research output: Contribution to journal › Article › Research › peer-review