Next Generation Cell Therapies for Cancer

  • Tiganis, Tony (Primary Chief Investigator (PCI))
  • Huntington, Nicholas (Chief Investigator (CI))
  • Darcy, Phillip (Associate Investigator (AI))
  • Zhang, Zhong-Yin (Associate Investigator (AI))
  • Cursons, Joseph (Associate Investigator (AI))
  • Vivier, Eric (Associate Investigator (AI))

Project: Research

Project Details

Project Description

Immune-based therapies are revolutionising the treatment of previously intractable cancers. In particular, therapies using chimeric antigen receptor (CAR) T cells have yielded unprecedented clinical responses in patients with B cell leukemia. However, the majority of cancers, in particular solid tumours, fail to respond to CAR T cell therapy. This proposal will take advantage of cutting-edge preclinical tumour models and innovative approaches to enhance CAR cell therapies in cancer.
StatusActive
Effective start/end date1/12/19 → 31/12/23
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Keywords

  • T cell immunotherapy
  • solid tumours
  • natural killer cells
  • protein tyrosine phosphatase (PTP)
  • tumour immunology