Project Details
Project Description
Immune-based therapies are revolutionising the treatment of previously intractable cancers. In particular, therapies using chimeric antigen receptor (CAR) T cells have yielded unprecedented clinical responses in patients with B cell leukemia. However, the majority of cancers, in particular solid tumours, fail to respond to CAR T cell therapy. This proposal will take advantage of cutting-edge preclinical tumour models and innovative approaches to enhance CAR cell therapies in cancer.
Status | Active |
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Effective start/end date | 1/12/19 → 31/12/23 |
Keywords
- T cell immunotherapy
- solid tumours
- natural killer cells
- protein tyrosine phosphatase (PTP)
- tumour immunology