New polymerisation processes for the synthesis of novel biopolymers

Novel homogeneous catalysis strategies will be used to generate well defined peptide polymers. The resulting polymer targets will be biomimetics of unique-functioning natural proteins. Stable analogues of antifreeze proteins, which are non-toxic and inhibit ice nucleation at extremely low concentrations in sub-Arctic animal and plant species, are needed for medical applications (organ/cell preservation) and food preservation. Resilin, a bioelastomer found in insects, is a near perfect rubber with extraordinary fatigue life. Structural mimetics will find medical (implants -heart valves, spinal discs) and industrial (accelerometers/actuators) uses. Polymerisation of immunogenic segments of infectious diseases will lead to synthetic vaccines.