New Methodology for the Manufacture of Opioid Pharmaceuticals and the Discovery of Novel Opiate Receptor Ligands

Project: Research

Project Description

This project will focus on the application of recently discovered methodology for the N-demethylation of opiates to the industrial manufacture of the semi-synthetic pharmaceutical opiates. These semi-synthetic opiates are important analgesic agents and are also used in the therapy of alcohol and opiate dependence.

The same N-demethylation methodology will be used to prepare fluorophore-tagged opiate receptor ligands and bivalent ligands to gain a better fundamental understanding of G protein-coupled receptor pharmacology.
StatusFinished
Effective start/end date30/06/1230/06/15

Funding

  • Australian Research Council (ARC): AUD210,000.00
  • GlaxoSmithKline (GSK) AUS : AUD120,000.00
  • Australian Research Council (ARC)
  • Monash University