New Methodology for the Manufacture of Opioid Pharmaceuticals and the Discovery of Novel Opiate Receptor Ligands

  • Scammells, Peter (Primary Chief Investigator (PCI))
  • Graham, Bimbil (Chief Investigator (CI))
  • Campbell, Scott (Partner Investigator (PI))

Project: Research

Project Details

Project Description

This project will focus on the application of recently discovered methodology for the N-demethylation of opiates to the industrial manufacture of the semi-synthetic pharmaceutical opiates. These semi-synthetic opiates are important analgesic agents and are also used in the therapy of alcohol and opiate dependence.

The same N-demethylation methodology will be used to prepare fluorophore-tagged opiate receptor ligands and bivalent ligands to gain a better fundamental understanding of G protein-coupled receptor pharmacology.
Effective start/end date30/06/1230/06/15


  • Australian Research Council (ARC): A$210,000.00
  • GlaxoSmithKline (GSK) Australia: A$120,000.00
  • Monash University