New metal catalysed tandem routes to nitrogen containing compounds

Olefin metathesis has emerged as a powerful tool for synthesising a wide range of organic molecules. High yielding metathesis of nitrogen containing molecules, however, still poses a significant challenge. Close examination of catalytic cycling and substrate structure will overcome these current limitations. Tandem catalytic processes and supported catalysts which function in aqueous environments will expedite routes to highly valuable commodities and facilitate extension into biological applications. New routes to pharmaceutical and polymer acyclic amines, heterocycles and peptidomimetics will be developed.