Neisseria gonorrhoeae secreted vesicles kill immune cells by disabling mitochondria

Naderer, Thomas (Primary Chief Investigator (PCI))

Project: Research

Status	Active
Effective start/end date	1/01/20 → 31/12/23

Funding

National Health and Medical Research Council (NHMRC) (Australia): A$774,180.00

Keywords

Neisseria gonorrhoeae
virulence factors
membrane protein
mitochondria
apoptosis

2 Article
1 Review Article

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway
Simpson, D. S., Pang, J., Weir, A., Kong, I. Y., Fritsch, M., Rashidi, M., Cooney, J. P., Davidson, K. C., Speir, M., Djajawi, T. M., Hughes, S., Mackiewicz, L., Dayton, M., Anderton, H., Doerflinger, M., Deng, Y., Huang, A. S., Conos, S. A., Tye, H., Chow, S. H., & 16 othersRahman, A., Norton, R. S., Naderer, T., Nicholson, S. E., Burgio, G., Man, S. M., Groom, J. R., Herold, M. J., Hawkins, E. D., Lawlor, K. E., Strasser, A., Silke, J., Pellegrini, M., Kashkar, H., Feltham, R. & Vince, J. E., 8 Mar 2022, In: Immunity. 55, 3, p. 423-441.e9 28 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

15 Citations (Scopus)
Bacterial outer membrane vesicles and host cell death signaling
Dhital, S., Deo, P., Stuart, I. & Naderer, T., Dec 2021, In: Trends in Microbiology. 29, 12, p. 1106-1116 11 p.
Research output: Contribution to journal › Review Article › Research › peer-review

13 Citations (Scopus)
Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation
Deo, P., Chow, S. H., Han, M-L., Speir, M., Huang, C., Schittenhelm, R. B., Dhital, S., Emery, J., Li, J., Kile, B. T., Vince, J. E., Lawlor, K. E. & Naderer, T., Nov 2020, In: Nature Microbiology. 5, 11, p. 1418–1427 10 p.
Research output: Contribution to journal › Article › Research › peer-review

52 Citations (Scopus)

Animal Research Platform (MARP)
Christine Findlay (Manager)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility
Genome Modification Platform
Jeanette Rientjes (Manager)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility
MASSIVE
Slava Kitaeff (Manager) & David Powell (Manager)
Office of the Vice-Provost (Research and Research Infrastructure)
Facility/equipment: Facility

Neisseria gonorrhoeae secreted vesicles kill immune cells by disabling mitochondria

Project Details

Funding

Keywords

Research output

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

Bacterial outer membrane vesicles and host cell death signaling

Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation

Equipment

Animal Research Platform (MARP)

Genome Modification Platform

MASSIVE