NAMs of Gq-coupled muscarinic acetylcholine receptors

Project: Research

Project Details

Project Description

1) To finish off key experiments with M1-M5 receptor and the 3 compounds previously selected (Obi, HI-6 and MMB4), captured under Aims 1, 2, 11 and 12 and to be completed by end of Q1.

2) To investigate some significant findings about 2 mutations at the M1 receptor that affect the binding of these compounds (M1 W101A and L102A), captured under Aim 3-6, and to be completed by the end of Q2.

3) To expand this on the M3 receptor where using site-directed mutagenesis we will generate the equivalent mutations as seen in M1 (residues 3.28A and 3.29A) to be assessed under Aims 7-10, and to be completed by the end of Q3.

4) To investigate 4 more compounds synthesised by the department of chemistry at the DST at M1-M5 mAChRs and these will be investigated under Aim 13 and 14. These will be sporadically completed over the course of the 9-months period.
Short titleNAMs of Gq
StatusFinished
Effective start/end date20/09/2128/02/23

Funding

  • Department of Defence (Australia): A$36,633.96

Keywords

  • allostery
  • muscarinic receptor