Multiple paths of TFH differentiation and their impact on B cell protection against infection

Groom, Joanna R (Primary Chief Investigator (PCI))
Jacobson, Kim (Chief Investigator (CI))
Shi, Wei (Chief Investigator (CI))

Biochemistry & Molecular Biology

Project: Research

Status	Finished
Effective start/end date	1/01/18 → 31/12/21

6 Article

Heterogeneous Tfh cell populations that develop during enteric helminth infection predict the quality of type 2 protective response
Zaini, A., Dalit, L., Sheikh, A. A., Zhang, Y., Thiele, D., Runting, J., Rodrigues, G., Ng, J., Bramhall, M., Scheer, S., Hailes, L., Groom, J. R., Good-Jacobson, K. L. & Zaph, C., Oct 2023, In: Mucosal Immunology. 16, 5, p. 642-657 16 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway
Simpson, D. S., Pang, J., Weir, A., Kong, I. Y., Fritsch, M., Rashidi, M., Cooney, J. P., Davidson, K. C., Speir, M., Djajawi, T. M., Hughes, S., Mackiewicz, L., Dayton, M., Anderton, H., Doerflinger, M., Deng, Y., Huang, A. S., Conos, S. A., Tye, H., Chow, S. H., & 16 othersRahman, A., Norton, R. S., Naderer, T., Nicholson, S. E., Burgio, G., Man, S. M., Groom, J. R., Herold, M. J., Hawkins, E. D., Lawlor, K. E., Strasser, A., Silke, J., Pellegrini, M., Kashkar, H., Feltham, R. & Vince, J. E., 8 Mar 2022, In: Immunity. 55, 3, p. 423-441.e9 28 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

77 Citations (Scopus)
The Histone Methyltransferase DOT1L Is Essential for Humoral Immune Responses
Kealy, L., Di Pietro, A., Hailes, L., Scheer, S., Dalit, L., Groom, J. R., Zaph, C. & Good-Jacobson, K. L., 15 Dec 2020, In: Cell Reports. 33, 11, 16 p., 108504.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

21 Citations (Scopus)

Animal Research Platform (MARP)
Christine Findlay (Manager)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility
FlowCore
Andrew Fryga (Manager)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility

Multiple paths of TFH differentiation and their impact on B cell protection against infection

Project Details

Research output

Heterogeneous Tfh cell populations that develop during enteric helminth infection predict the quality of type 2 protective response

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

The Histone Methyltransferase DOT1L Is Essential for Humoral Immune Responses

Equipment

Animal Research Platform (MARP)

FlowCore