Multi-drug dry powder inhalation systems for effective treatment of chronic obstructive pulmonary disease

  • Stewart, Peter (Primary Chief Investigator (PCI))
  • Honnery, Damon (Chief Investigator (CI))
  • Traini, Daniela (Chief Investigator (CI))
  • Young, Paul (Chief Investigator (CI))

Project: Research

Project Description

We will develop a dry powder inhaler (DPI) and multi-drug therapy for chronic obstructive pulmonary disease (COPD). Current treatments require up to 5 medicines daily & current devices are inefficient. A micron sized inhalation powder that has a surface chemistry independant of the combination of drugs used will be formulated. Computational fluid dynamics will be used to predict powder de-agglomeration mechanisms and 3D-prototyping used to prepare working DPIs. Aerosolisation performance will be studied using 3D velocimetry & high-speed holography. We will advance knowledge in the physical & chemical sciences & develop techniques that have wide application. Ultimately, a novel therapeutic approach will have been developed for COPD.
StatusFinished
Effective start/end date1/01/1231/12/14

Funding

  • Australian Research Council (ARC): AUD165,000.00
  • Australian Research Council (ARC)