Research output per year
Research output per year
Project Details
Project Description
We will develop a dry powder inhaler (DPI) and multi-drug therapy for chronic obstructive pulmonary disease (COPD). Current treatments require up to 5 medicines daily & current devices are inefficient. A micron sized inhalation powder that has a surface chemistry independant of the combination of drugs used will be formulated. Computational fluid dynamics will be used to predict powder de-agglomeration mechanisms and 3D-prototyping used to prepare working DPIs. Aerosolisation performance will be studied using 3D velocimetry & high-speed holography. We will advance knowledge in the physical & chemical sciences & develop techniques that have wide application. Ultimately, a novel therapeutic approach will have been developed for COPD.
| Status | Finished |
|---|---|
| Effective start/end date | 1/01/12 → 31/12/14 |
Funding
- Australian Research Council (ARC): A$165,000.00
Research output
- 2 Article
-
Temporally and Spatially Resolved x-ray Fluorescence Measurements of in-situ Drug Concentration in Metered-Dose Inhaler Sprays
Duke, D. J., Kastengren, A. L., Mason-Smith, N., Chen, Y., Young, P. M., Traini, D., Lewis, D. A., Edgington-Mitchell, D. & Honnery, D., 1 Apr 2016, In: Pharmaceutical Research. 33, 4, p. 816-825 10 p.Research output: Contribution to journal › Article › Research › peer-review
14 Citations (Scopus) -
A novel high-speed imaging technique to predict the macroscopic spray characteristics of solution based pressurised metered dose inhalers
Buchmann, N. A., Duke, D. J., Shakiba , S. A., Mitchell, D. M., Stewart, P. J., Traini, D., Young, P. M., Lewis, D. A., Soria, J. & Honnery, D. R., 2014, In: Pharmaceutical Research. 31, 11, p. 2963 - 2974 12 p.Research output: Contribution to journal › Article › Research › peer-review
17 Citations (Scopus)