Research output per year
Research output per year
Project Details
Project Description
We will develop a dry powder inhaler (DPI) and multi-drug therapy for chronic obstructive pulmonary disease (COPD). Current treatments require up to 5 medicines daily & current devices are inefficient. A micron sized inhalation powder that has a surface chemistry independant of the combination of drugs used will be formulated. Computational fluid dynamics will be used to predict powder de-agglomeration mechanisms and 3D-prototyping used to prepare working DPIs. Aerosolisation performance will be studied using 3D velocimetry & high-speed holography. We will advance knowledge in the physical & chemical sciences & develop techniques that have wide application. Ultimately, a novel therapeutic approach will have been developed for COPD.
| Status | Finished |
|---|---|
| Effective start/end date | 1/01/12 → 31/12/14 |
Funding
- Australian Research Council (ARC): A$165,000.00
Research output
- 2 Article
-
Temporally and Spatially Resolved x-ray Fluorescence Measurements of in-situ Drug Concentration in Metered-Dose Inhaler Sprays
Duke, D. J., Kastengren, A. L., Mason-Smith, N., Chen, Y., Young, P. M., Traini, D., Lewis, D. A., Edgington-Mitchell, D. & Honnery, D., 1 Apr 2016, In: Pharmaceutical Research. 33, 4, p. 816-825 10 p.Research output: Contribution to journal › Article › Research › peer-review
10 Citations (Scopus) -
A novel high-speed imaging technique to predict the macroscopic spray characteristics of solution based pressurised metered dose inhalers
Buchmann, N. A., Duke, D. J., Shakiba, S. A., Mitchell, D. M., Stewart, P. J., Traini, D., Young, P. M., Lewis, D. A., Soria, J. & Honnery, D. R., 2014, In: Pharmaceutical Research. 31, 11, p. 2963 - 2974 12 p.Research output: Contribution to journal › Article › Research › peer-review
12 Citations (Scopus)