Molecular regulation of blood cell production and function

Research output

Research output per year 2011 2011 2012 2019

• 15 Article

Research output per year

Research output per year

Search results

• 2019

  A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

  van Delft, M. F., Chappaz, S., Khakham, Y., Bui, C. T., Debrincat, M. A., Lowes, K. N., Brouwer, J. M., Grohmann, C., Sharp, P. P., Dagley, L. F., Li, L., McArthur, K., Luo, M. X., Chin, H. S., Fairlie, W. D., Lee, E. F., Segal, D., Duflocq, S., Lessene, R. & Bernard, S. & 16 others, Peilleron, L., Nguyen, T., Miles, C., Wan, S. S., Lane, R. M., Wardak, A., Lackovic, K., Colman, P. M., Sandow, J. J., Webb, A. I., Czabotar, P. E., Dewson, G., Watson, K. G., Huang, D. C. S., Lessene, G. & Kile, B. T., 1 Nov 2019, In: Nature Chemical Biology. 15, 11, p. 1057-1066 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  33 Citations (Scopus)
• 2018

  NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease

  Tye, H., Yu, C. H., Simms, L. A., de Zoete, M. R., Kim, M. L., Zakrzewski, M., Penington, J. S., Harapas, C. R., Souza-Fonseca-Guimaraes, F., Wockner, L. F., Preaudet, A., Mielke, L. A., Wilcox, S. A., Ogura, Y., Corr, S. C., Kanojia, K., Kouremenos, K. A., De Souza, D. P., McConville, M. J. & Flavell, R. A. & 6 others, Gerlic, M., Kile, B. T., Papenfuss, A. T., Putoczki, T. L., Radford-Smith, G. L. & Masters, S. L., 13 Sept 2018, In: Nature Communications. 9, 1, 11 p., 3728.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

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  98 Citations (Scopus)
• 2016

  IL-18 production from the NLRP1 inflammasome prevents obesity and metabolic syndrome

  Murphy, A. J., Kraakman, M. J., Kammoun, H. L., Dragoljevic, D., Lee, M. K. S., Lawlor, K. E., Wentworth, J. M., Vasanthakumar, A., Gerlic, M., Whitehead, L. W., DiRago, L., Cengia, L., Lane, R. M., Metcalf, D., Vince, J. E., Harrison, L. C., Kallies, A., Kile, B. T., Croker, B. A. & Febbraio, M. A. & 1 others, Masters, S. L., 12 Jan 2016, In: Cell Metabolism. 23, 1, p. 155-164 10 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

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  144 Citations (Scopus)
• 2013

  Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease

  Mason, K. D., Lin, A., Robb, L., Josefsson, E. C., Henley, K. J., Gray, D. H. D., Kile, B. T., Roberts, A. W., Strasser, A., Huang, D. C. S., Waring, P. & O'Reilly, L. A., 12 Feb 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 7, p. 2599-2604 6 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  46 Citations (Scopus)

• The role of leukemia inhibitory factor in tubal ectopic pregnancy

  Krishnan, T., Winship, A., Sonderegger, S., Menkhorst, E., Horne, A. W., Brown, J., Zhang, J.-G., Nicola, N. A., Tong, S. & Dimitriadis, E., Nov 2013, In: Placenta. 34, 11, p. 1014-1019 6 p.

  Research output: Contribution to journal › Article › Research › peer-review
  28 Citations (Scopus)
• 2012

  Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

  White, M. J., Schoenwaelder, S. M., Josefsson, E. C., Jarman, K. E., Henley, K. J., James, C., Debrincat, M. A., Jackson, S. P., Huang, D. C. S. & Kile, B. T., 3 May 2012, In: Blood. 119, 18, p. 4283-4290 8 p., 18.

  Research output: Contribution to journal › Article › Research › peer-review
  70 Citations (Scopus)

• Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia

  Carmichael, C. L., Metcalf, D., Henley, K. J., Kruse, E. A., Di Ragoa, L., Mifsud, S., Alexander, W. S. & Kile, B. T., 18 Sept 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 38, p. 15437-15442 6 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  47 Citations (Scopus)

• NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells

  Masters, S. L., Gerlic, M., Metcalf, D., Preston, S., Pellegrini, M., O'Donnell, J. A., McArthur, K., Baldwin, T. M., Chevrier, S., Nowell, C. J., Cengia, L. H., Henley, K. J., Collinge, J. E., Kastner, D. L., Feigenbaum, L., Hilton, D. J., Alexander, W. S., Kile, B. T. & Croker, B. A., 14 Dec 2012, In: Immunity. 37, 6, p. 1009-1023 15 p.

  Research output: Contribution to journal › Article › Research › peer-review
  257 Citations (Scopus)

• The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments

  Zhang, J.-G., Czabotar, P. E., Policheni, A. N., Caminschi, I., Wan, S. S., Kitsoulis, S., Tullett, K. M., Robin, A. Y., Brammananth, R., van Delft, M. F., Lu, J., O'Reilly, L. A., Josefsson, E. C., Kile, B. T., Chin, W. J., Mintern, J. D., Olshina, M. A., Wong, W., Baum, J. & Wright, M. D. & 7 others, Huang, D. C. S., Mohandas, N., Coppel, R. L., Colman, P. M., Nicola, N. A., Shortman, K. & Lahoud, M. H., 2012, In: Immunity. 36, 4, p. 646-657 12 p.

  Research output: Contribution to journal › Article › Research › peer-review
  270 Citations (Scopus)

• Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor

  Lindqvist, L., Vikstrom, I., Chambers, J., McArthur, K., Anderson, M. A., Henley, K., Happo, L., Cluse, L., Johnstone, R., Roberts, A., Kile, B., Croker, B., Burns, C., Rizzacasa, M., Strasser, A. & Huang, D., Oct 2012, In: Cell Death & Disease. 3, 10, 9 p., e409.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

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  44 Citations (Scopus)
• 2011

  Bcl-x_L-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

  Schoenwaelder, S. M., Jarman, K. E., Gardiner, E. E., Hua, M., Qiao, J., White, M. J., Josefsson, E. C., Alwis, I., Ono, A., Willcox, A., Andrews, R. K., Mason, K. D., Salem, H. H., Huang, D. C. S., Kile, B. T., Roberts, A. W. & Jackson, S. P., 2011, In: Blood. 118, 6, p. 1663-1674 12 p.

  Research output: Contribution to journal › Article › Research › peer-review
  279 Citations (Scopus)

• ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification

  Taoudi, S., Bee, T., Hilton, A., Knezevic, K., Scott, J., Willson, T. A., Collin, C., Thomas, T., Voss, A. K., Kile, B. T., Alexander, W. S., Pimanda, J. E. & Hilton, D. J., Feb 2011, In: Genes & Development. 25, 3, p. 251-262 12 p.

  Research output: Contribution to journal › Article › Research › peer-review
  95 Citations (Scopus)

• Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice

  Ng, A. P., Loughran, S. J., Metcalf, D., Hyland, C. D., de Graaf, C. A., Hu, Y., Smyth, G. K., Hilton, D. J., Kile, B. T. & Alexander, W. S., 1 Sept 2011, In: Blood. 118, 9, p. 2454-2461 8 p.

  Research output: Contribution to journal › Article › Research › peer-review
  49 Citations (Scopus)

• Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

  Josefsson, E. C., James, C., Henley, K. J., Debrincat, M. A., Rogers, K. L., Dowling, M. R., White, M. J., Kruse, E. A., Lane, R. M., Ellis, S., Nurden, P., Mason, K. D., O'Reilly, L. A., Roberts, A. W., Metcalf, D., Huang, D. C. S. & Kile, B. T., 26 Sept 2011, In: Journal of Experimental Medicine. 208, 10, p. 2017-2031 15 p.

  Research output: Contribution to journal › Article › Research › peer-review
  158 Citations (Scopus)

• Vaginally administered PEGylated LIF Antagonist blocked embryo implantation and eliminated non-target effects on bone in mice

  Menkhorst, E., Sims, N. A., Morgan, P. O., Soo, P., Poulton, I. J., Metcalf, D., Alexandrou, E., Gresle, M., Salamonsen, L. A., Butzkueven, H., Nicola, N. A. & Dimitriadis, E., 2011, In: PLoS ONE. 6, 5, p. 1 - 9 9 p., e19665.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  30 Citations (Scopus)