Molecular regulation of blood cell production and function

Norton, Raymond (Primary Chief Investigator (PCI))
Alexander, Warren S. (Chief Investigator (CI))
Hilton, Douglas J. (Chief Investigator (CI))
Metcalf, Donald (Chief Investigator (CI))
Nicola, Nicos (Chief Investigator (CI))
Robb, Lorraine G. (Chief Investigator (CI))
Roberts, Andrew W. (Chief Investigator (CI))
Starr, Robyn (Chief Investigator (CI))
Zhang, Jian-Guo (Chief Investigator (CI))

Medicinal Chemistry

Project: Research

Status	Finished
Effective start/end date	19/07/10 → 31/12/11

Funding

National Health and Medical Research Council (NHMRC) (Australia): A$492,950.00

15 Article

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis
van Delft, M. F., Chappaz, S., Khakham, Y., Bui, C. T., Debrincat, M. A., Lowes, K. N., Brouwer, J. M., Grohmann, C., Sharp, P. P., Dagley, L. F., Li, L., McArthur, K., Luo, M. X., Chin, H. S., Fairlie, W. D., Lee, E. F., Segal, D., Duflocq, S., Lessene, R., Bernard, S., & 16 othersPeilleron, L., Nguyen, T., Miles, C., Wan, S. S., Lane, R. M., Wardak, A., Lackovic, K., Colman, P. M., Sandow, J. J., Webb, A. I., Czabotar, P. E., Dewson, G., Watson, K. G., Huang, D. C. S., Lessene, G. & Kile, B. T., 1 Nov 2019, In: Nature Chemical Biology. 15, 11, p. 1057-1066 10 p.
Research output: Contribution to journal › Article › Research › peer-review

30 Citations (Scopus)
NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease
Tye, H., Yu, C. H., Simms, L. A., de Zoete, M. R., Kim, M. L., Zakrzewski, M., Penington, J. S., Harapas, C. R., Souza-Fonseca-Guimaraes, F., Wockner, L. F., Preaudet, A., Mielke, L. A., Wilcox, S. A., Ogura, Y., Corr, S. C., Kanojia, K., Kouremenos, K. A., De Souza, D. P., McConville, M. J., Flavell, R. A., & 6 othersGerlic, M., Kile, B. T., Papenfuss, A. T., Putoczki, T. L., Radford-Smith, G. L. & Masters, S. L., 13 Sept 2018, In: Nature Communications. 9, 1, 11 p., 3728.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
File

85 Citations (Scopus)
IL-18 production from the NLRP1 inflammasome prevents obesity and metabolic syndrome
Murphy, A. J., Kraakman, M. J., Kammoun, H. L., Dragoljevic, D., Lee, M. K. S., Lawlor, K. E., Wentworth, J. M., Vasanthakumar, A., Gerlic, M., Whitehead, L. W., DiRago, L., Cengia, L., Lane, R. M., Metcalf, D., Vince, J. E., Harrison, L. C., Kallies, A., Kile, B. T., Croker, B. A., Febbraio, M. A., & 1 othersMasters, S. L., 12 Jan 2016, In: Cell Metabolism. 23, 1, p. 155-164 10 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
File

131 Citations (Scopus)

Molecular regulation of blood cell production and function

Project Details

Funding

Research output

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease

IL-18 production from the NLRP1 inflammasome prevents obesity and metabolic syndrome