Molecular markers of phenotype, therapeutic responsiveness and prognosis in human cancers - Improving characterisation of human cancers in order to optimise clinical management and treatment.

Daly, Roger (Primary Chief Investigator (PCI))
Horvath, Lisa G (Partner Investigator (PI))
Kench, James G. (Partner Investigator (PI))
Millar, Ewan (Partner Investigator (PI))
O'Toole, Sandra A. (Partner Investigator (PI))
Ormandy, Christopher J. (Partner Investigator (PI))

Biochemistry & Molecular Biology

Project: Research

Status	Finished
Effective start/end date	1/03/13 → 31/12/13

Funding

National Health and Medical Research Council (NHMRC) (Australia): A$400,000.00

6 Article

INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
Rodgers, S. J., Ooms, L. M., Oorschot, V. M. J., Schittenhelm, R. B., Nguyen, E. V., Hamila, S. A., Rynkiewicz, N., Gurung, R., Eramo, M. J., Sriratana, A., Fedele, C. G., Caramia, F., Loi, S., Kerr, G., Abud, H. E., Ramm, G., Papa, A., Ellisdon, A. M., Daly, R. J. & McLean, C. A. & 1 others, Mitchell, C. A., 2021, In: Nature Communications. 12, 1, 19 p., 3140.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

44 Citations (Scopus)
Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer
Dreyer, S. B., Upstill-Goddard, R., Paulus-Hock, V., Paris, C., Lampraki, E. M., Dray, E., Serrels, B., Caligiuri, G., Rebus, S., Plenker, D., Galluzzo, Z., Brunton, H., Cunningham, R., Tesson, M., Nourse, C., Bailey, U. M., Jones, M. D., Moran-Jones, K., Wright, D. W. & Duthie, F. & 36 others, Oien, K., Evers, L., McKay, C. J., McGregor, G. A., Gulati, A., Bajrami, I., Pettitt, S., Dziubinski, M. L., Candido, J., Balkwill, F., Barry, S. T., Grützmann, R., Rahib, L., Glasgow Precision Oncology Laboratory, Australian Pancreatic Cancer Genome Initiative (APGI), Johns, A. L., Pajic, M., Froeling, F. E. M., Beer, P., Musgrove, E. A., Petersen, G. M., Ashworth, A., Frame, M. C., Crawford, H. C., Simeone, D. M., Lord, C., Mukhopadhyay, D., Pilarsky, C., Tuveson, D. A., Cooke, S. L., Jamieson, N. B., Morton, J. P., Sansom, O. J., Bailey, P. J., Biankin, A. V. & Chang, D. K., Jan 2021, In: Gastroenterology. 160, 1, p. 362-377.e13 29 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

94 Citations (Scopus)
Effect of FAK inhibitor VS-6063 (defactinib) on docetaxel efficacy in prostate cancer
Lin, H. M., Lee, B. Y., Castillo, L., Spielman, C., Grogan, J., Yeung, N. K., Kench, J. G., Stricker, P. D., Haynes, A. M., Centenera, M. M., Butler, L. M., Shreeve, S. M., Horvath, L. G. & Daly, R. J., 1 Mar 2018, In: The Prostate. 78, 4, p. 308-317 10 p.
Research output: Contribution to journal › Article › Research › peer-review

57 Citations (Scopus)

Molecular markers of phenotype, therapeutic responsiveness and prognosis in human cancers - Improving characterisation of human cancers in order to optimise clinical management and treatment.

Project Details

Funding

Research output

INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

Effect of FAK inhibitor VS-6063 (defactinib) on docetaxel efficacy in prostate cancer