Molecular determinants of drug binding and selectivity at muscarinic acetylcholine receptors

Research output

Research output per year 2018 2021 2023 2024

• 9 Article

Research output per year

Research output per year

Search results

• 2024

  Importance of receptor expression in the classification of novel ligands at the M₂ muscarinic acetylcholine receptor

  Jiang, Y., Yeasmin, M., Gondin, A. B., Christopoulos, A., Valant, C., Burger, W. A. C. & Thal, D. M., Jul 2024, In: British Journal of Pharmacology. 181, 14, p. 2338-2350 13 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  8 Citations (Scopus)
• 2023

  Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

  Vuckovic, Z., Wang, J., Pham, V., Mobbs, J. I., Belousoff, M. J., Bhattarai, A., Burger, W. A. C., Thompson, G., Yeasmin, M., Nawaratne, V., Leach, K., van der Westhuizen, E. T., Khajehali, E., Liang, Y. L., Glukhova, A., Wootten, D., Lindsley, C. W., Tobin, A., Sexton, P. & Danev, R. & 4 others, Valant, C., Miao, Y., Christopoulos, A. & Thal, D. M., 30 May 2023, In: eLife. 12, 52 p., e83477.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  18 Citations (Scopus)

• Structural basis of efficacy-driven ligand selectivity at GPCRs

  Powers, A. S., Pham, V., Burger, W. A. C., Thompson, G., Laloudakis, Y., Barnes, N., Sexton, P. M., Paul, S. M., Christopoulos, A., Thal, D. M., Felder, C. C., Valant, C. & Dror, R. O., 13 Feb 2023, In: Nature Chemical Biology. 19, p. 805–814 22 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  27 Citations (Scopus)

• Xanomeline displays concomitant orthosteric and allosteric binding modes at the M₄ mAChR

  Burger, W. A. C., Pham, V., Vuckovic, Z., Powers, A. S., Mobbs, J. I., Laloudakis, Y., Glukhova, A., Wootten, D., Tobin, A. B., Sexton, P. M., Paul, S. M., Felder, C. C., Danev, R., Dror, R. O., Christopoulos, A., Valant, C. & Thal, D. M., Dec 2023, In: Nature Communications. 14, 1, 11 p., 5440.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  18 Citations (Scopus)
• 2022

  Selective G protein signaling driven by substance P–neurokinin receptor dynamics

  Harris, J. A., Faust, B., Gondin, A. B., Dämgen, M. A., Suomivuori, C. M., Veldhuis, N. A., Cheng, Y., Dror, R. O., Thal, D. M. & Manglik, A., Jan 2022, In: Nature Chemical Biology. 18, 1, p. 109–115 7 p.

  Research output: Contribution to journal › Article › Research › peer-review
  58 Citations (Scopus)
• 2021

  Identification of a Novel Allosteric Site at the M₅Muscarinic Acetylcholine Receptor

  Burger, W. A. C., Gentry, P. R., Berizzi, A. E., Vuckovic, Z., Van Der Westhuizen, E. T., Thompson, G., Yeasmin, M., Lindsley, C. W., Sexton, P. M., Langmead, C. J., Tobin, A. B., Christopoulos, A., Valant, C. & Thal, D. M., 18 Aug 2021, In: ACS Chemical Neuroscience. 12, 16, p. 3112-3123 12 p.

  Research output: Contribution to journal › Article › Research › peer-review
  8 Citations (Scopus)

• Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

  Mobbs, J. I., Belousoff, M. J., Harikumar, K. G., Piper, S. J., Xu, X., Furness, S. G. B., Venugopal, H., Christopoulos, A., Danev, R., Wootten, D., Thal, D. M., Miller, L. J. & Sexton, P. M., 4 Jun 2021, In: PLoS Biology. 19, 6, 28 p., e3001295.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  45 Citations (Scopus)
• 2019

  Crystal structure of the M₅ muscarinic acetylcholine receptor

  Vuckovic, Z., Gentry, P. R., Berizzi, A. E., Hirata, K., Varghese, S., Thompson, G., van der Westhuizen, E. T., Burger, W. A. C., Rahmani, R., Valant, C., Langmead, C. J., Lindsley, C. W., Baell, J. B., Tobin, A. B., Sexton, P. M., Christopoulos, A. & Thal, D. M., 17 Dec 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 51, p. 26001-26007 7 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  51 Citations (Scopus)
• 2018

  Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors

  Burger, W. A. C., Sexton, P. M., Christopoulos, A. & Thal, D. M., 1 Oct 2018, In: Journal of General Physiology. 150, 10, p. 1360-1372 13 p.

  Research output: Contribution to journal › Article › Research › peer-review
  40 Citations (Scopus)