Molecular determinants of drug binding and selectivity at muscarinic acetylcholine receptors

Thal, David (Primary Chief Investigator (PCI))
Gooley, Paul Raymond (Chief Investigator (CI))
Dror, Ron (Chief Investigator (CI))

Drug Discovery Biology

Project: Research

Status	Finished
Effective start/end date	1/01/18 → 30/09/22

Funding

National Health and Medical Research Council (NHMRC) (Australia): A$816,866.00

9 Article

Importance of receptor expression in the classification of novel ligands at the M₂ muscarinic acetylcholine receptor
Jiang, Y., Yeasmin, M., Gondin, A. B., Christopoulos, A., Valant, C., Burger, W. A. C. & Thal, D. M., Jul 2024, In: British Journal of Pharmacology. 181, 14, p. 2338-2350 13 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

8 Citations (Scopus)
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
Vuckovic, Z., Wang, J., Pham, V., Mobbs, J. I., Belousoff, M. J., Bhattarai, A., Burger, W. A. C., Thompson, G., Yeasmin, M., Nawaratne, V., Leach, K., van der Westhuizen, E. T., Khajehali, E., Liang, Y. L., Glukhova, A., Wootten, D., Lindsley, C. W., Tobin, A., Sexton, P. & Danev, R. & 4 others, Valant, C., Miao, Y., Christopoulos, A. & Thal, D. M., 30 May 2023, In: eLife. 12, 52 p., e83477.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

17 Citations (Scopus)
Structural basis of efficacy-driven ligand selectivity at GPCRs
Powers, A. S., Pham, V., Burger, W. A. C., Thompson, G., Laloudakis, Y., Barnes, N., Sexton, P. M., Paul, S. M., Christopoulos, A., Thal, D. M., Felder, C. C., Valant, C. & Dror, R. O., 13 Feb 2023, In: Nature Chemical Biology. 19, p. 805–814 22 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

25 Citations (Scopus)

Australian Synchrotron
Office of the Vice-Provost (Research and Research Infrastructure)
Facility/equipment: Facility
MASSIVE
Powell, D. (Manager) & Tan, G. (Manager)
Office of the Vice-Provost (Research and Research Infrastructure)
Facility/equipment: Facility
Ramaciotti Centre for Cryo-Electron Microscopy
Ramm, G. (Manager), Crawford, S. A. (Operator), Venugopal, H. (Operator), Clark, J. M. (Operator) & Gervinskas, G. (Operator)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility