Molecular characterisation of pore-forming proteins as pest control agents

This project aims to utilise protein engineering, structural biology, and biochemistry to characterise the function of
key members of the aerolysin/epsilon toxin/Toxin_10 pore-forming protein superfamily. Pore formation is a ubiquitous mechanism deployed by all kingdoms as defences against invading organisms. The expected outcomes of this project include the development of novel techniques aimed, broadly, at studying pore-forming proteins during the assembly pathway. This project should be of benefit to the wider research community by improving our understanding of pore-forming proteins as potential pest control agents.