Molecular and structural basis of signalling by TIR domain-containing adaptors in TLR pathways

Project: Research

Status	Finished
Effective start/end date	1/01/11 → 31/12/13

Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling
Hughes, M. M., Lavrencic, P., Coll, R. C., Ve, T., Ryan, D. G., Williams, N. C., Menon, D., Mansell, A., Board, P. G., Mobli, M., Kobe, B. & O’Neill, L. A. J., 8 Aug 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 32, p. E6480-E6489 10 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
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31 Citations (Scopus)
Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling
Ve, T., Vajjhala, P. R., Hedger, A., Croll, T., Dimaio, F., Horsefield, S., Yu, X., Lavrencic, P., Hassan, Z., Morgan, G. P., Mansell, A., Mobli, M., O'Carroll, A., Chauvin, B., Gambin, Y., Sierecki, E., Landsberg, M. J., Stacey, K. J., Egelman, E. H. & Kobe, B., 7 Sept 2017, In: Nature Structural & Molecular Biology. 24, 9, p. 743-751 9 p.
Research output: Contribution to journal › Article › Research › peer-review

137 Citations (Scopus)
TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target
Ullah, M. O., Sweet, M. J., Mansell, A., Kellie, S. & Kobe, B., 1 Jul 2016, In: Journal of Leukocyte Biology. 100, 1, p. 27-45 19 p.
Research output: Contribution to journal › Review Article › Research › peer-review

168 Citations (Scopus)

Project Details