Molecular and cellular mechanisms of action of novel plant guanylyl cyclase enzymes - a new class of overlapping dual-domain molecules

  • Irving, Helen (Primary Chief Investigator (PCI))
  • Manallack, David (Chief Investigator (CI))
  • Gehring, Christoph (Partner Investigator (PI))

Project: Research

Project Details

Project Description

Cyclic GMP is a key signalling molecule present in all organisms and produced by the catalytic action of
guanylyl cyclase enzymes. We have identified a new family of plant guanylyl cyclases that have regulatory
roles in plant growth and development and responses to pathogen attack. These molecules are highly
unusual and very different to the animal enzymes as the catalytic centre is embedded within another enzyme
catalytic domain. We aim to investigate the mechanism(s) of action and regulation of this novel family of
enzymes to understand their dual enzymatic function focussing on their biological role in plants. The
outcomes will provide major insights into enzyme action and signalling processes in general and in plants in
Effective start/end date4/01/1130/09/14


  • Australian Research Council (ARC): A$285,000.00
  • Monash University