Molecular and Cellular basis of inflammatory and immunodeficiency diseases

Mackay, Charles (Primary Chief Investigator (PCI))
Brink, Robert (Chief Investigator (CI))
Cook, Matthew (Chief Investigator (CI))
Goodnow, Chris (Chief Investigator (CI))
Mackay-Fisson, Fabienne (Chief Investigator (CI))
Sprent, Jonathon (Chief Investigator (CI))
Tangye, Stuart (Chief Investigator (CI))
Vinuesa, Carola G. (Chief Investigator (CI))

Immunology Alfred Hospital

Project: Research

Status	Finished
Effective start/end date	1/01/12 → 31/12/16

Funding

National Health and Medical Research Council (NHMRC) (Australia): A$979,490.00
National Health and Medical Research Council (NHMRC) (Australia): A$2,002,320.00
National Health and Medical Research Council (NHMRC) (Australia): A$1,466,415.00

15 Article
2 Review Article

Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens
Burnett, D. L., Schofield, P., Langley, D. B., Jackson, J., Bourne, K., Wilson, E., Porebski, B. T., Buckle, A. M., Brink, R., Goodnow, C. C. & Christ, D., 8 Sept 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 36, p. 22341-22350 10 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
File

14 Citations (Scopus)
A divergent transcriptional landscape underpins the development and functional branching of MAIT cells
Koay, H. F., Su, S., Amann-Zalcenstein, D., Daley, S. R., Comerford, I., Miosge, L., Whyte, C. E., Konstantinov, I. E., d'Udekem, Y., Baldwin, T., Hickey, P. F., Berzins, S. P., Mak, J. Y. W., Sontani, Y., Roots, C. M., Sidwell, T., Kallies, A., Chen, Z., Nüssing, S., Kedzierska, K., & 11 othersMackay, L. K., McColl, S. R., Deenick, E. K., Fairlie, D. P., McCluskey, J., Goodnow, C. C., Ritchie, M. E., Belz, G. T., Naik, S. H., Pellicci, D. G. & Godfrey, D. I., 22 Nov 2019, In: Science Immunology. 4, 41, 16 p., 6039.
Research output: Contribution to journal › Article › Research › peer-review

74 Citations (Scopus)
Deletion of self-reactive CCR7– thymocytes in the absence of MHC expression on thymic epithelial cells
Wirasinha, R. C., Chan, A., Yap, J. Y., Hu, D. Y., Teh, C. E., Gray, D. H. D., Goodnow, C. C. & Daley, S. R., 24 Apr 2019, In: Cell Death and Differentiation. 26, p. 2727-2739 13 p.
Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Molecular and Cellular basis of inflammatory and immunodeficiency diseases

Project Details

Funding

Research output

Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

Deletion of self-reactive CCR7– thymocytes in the absence of MHC expression on thymic epithelial cells