Mitigating the risks of mitochondrial donation

  • Carroll, John (Primary Chief Investigator (PCI))
  • Mann, Jeff (Chief Investigator (CI))
  • Herbert, Mary (Chief Investigator (CI))
  • Zander-Fox, Deirdre L (Chief Investigator (CI))

Project: Research

Project Details

Project Description

Mitochondrial donation in eggs is a possible way to avoid mitochondrial DNA disease. However, there are safety concerns. To address these, we will perform the procedure in mice to see if (1) the procedure affects egg viability, (2) the donor egg causes physical or behavioural changes, (3) carry-over mutant mitochondria lead to disease, and (4) carry-over risk can be minimized. Our findings will serve as a reference for the eventual adoption or non-adoption of the technology.
Short titleSafety of mitochondrial donation
AcronymNHOMD
StatusActive
Effective start/end date1/01/21 → 31/12/24
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Keywords

  • mitochondrial disease
  • mitochondrial DNA (mtDNA)
  • oocyte
  • assisted reproductive technology (ART)
  • mitochondrial genetics