Project Details
Project Description
Mitochondrial donation in eggs is a possible way to avoid mitochondrial DNA disease. However, there are safety concerns. To address these, we will perform the procedure in mice to see if (1) the procedure affects egg viability, (2) the donor egg causes physical or behavioural changes, (3) carry-over mutant mitochondria lead to disease, and (4) carry-over risk can be minimized. Our findings will serve as a reference for the eventual adoption or non-adoption of the technology.
Short title | Safety of mitochondrial donation |
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Acronym | NHOMD |
Status | Active |
Effective start/end date | 1/01/21 → 31/12/24 |
Keywords
- mitochondrial disease
- mitochondrial DNA (mtDNA)
- oocyte
- assisted reproductive technology (ART)
- mitochondrial genetics
Equipment
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Animal Research Platform (MARP)
Tanya Lennane (Manager)
Faculty of Medicine Nursing and Health Sciences Research PlatformsFacility/equipment: Facility
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Bioinformatics Platform
David Powell (Manager)
Faculty of Medicine Nursing and Health Sciences Research PlatformsFacility/equipment: Facility
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Biomedical Imaging (MBI)
Gary Egan (Manager) & Kylie Reid (Manager)
Office of the Vice-Provost (Research and Research Infrastructure)Facility/equipment: Facility