microRNAs and the control of T lymphocyte differentiation, function and malignant transformation

  • Yu, Di (Primary Chief Investigator (PCI))

Project: Research

Project Description

Follicular helper T (Tfh) cells is essential for helping B cells to mount high-affinity and long-term antibody
protection against various pathogens. We have recently identified the transcription factor B-cell lymphoma 6
(Bcl6) directs Tfh cell differentiation. In addition, the aberrant expression of Bcl6 can lead to the lymphocyte
malignant transformation. The aim of this project is to systemically investigate the emerging role of
microRNAs in the regulatory networks underpinning the Bcl6-mediated T cell differentiation and malignant
transformation. Therefore, this project not only addresses fundamental questions in molecular regulation but
also provides new pathways to design better vaccination strategies and treat certain lymphomas.
StatusFinished
Effective start/end date4/01/1130/06/14

Funding

  • Australian Research Council (ARC): AUD315,000.00
  • Australian Research Council (ARC)
  • Monash University