Mechanistic understanding of biased agonism and dimerisation for co-targeting incretin receptors for metabolic diseases

Project: Research

Status	Active
Effective start/end date	1/01/24 → 31/12/28

Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors
Cao, J., Belousoff, M. J., Johnson, R. M., Keov, P., Mariam, Z., Deganutti, G., Christopoulos, G., Hick, C. A., Reedtz-Runge, S., Glendorf, T., Ballarín-González, B., Raun, K., Bayly-Jones, C., Wootten, D. & Sexton, P. M., 10 Apr 2025, In: Nature Communications. 16, 1, 15 p., 3389.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

11 Link opens in a new tab Citations (Scopus)
Unique Biased Agonism Profile of βCGRP on CGRP Family Receptors
Mennen, G., Ying, Z., Fletcher, M. M., Abdur Razzak, M., Humphrys, L., Josephs, T. M., Sexton, P. M., Wootten, D. & Zhao, P., 17 Jun 2025, In: Biochemistry. 64, 12, p. 2556–2576 21 p.
Research output: Contribution to journal › Article › Research › peer-review

2 Link opens in a new tab Citations (Scopus)
Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein
Cao, J., Belousoff, M. J., Danev, R., Christopoulos, A., Wootten, D. & Sexton, P. M., 7 May 2024, In: Biochemistry. 63, 9, p. 1089-1096 8 p.
Research output: Contribution to journal › Article › Research › peer-review

8 Link opens in a new tab Citations (Scopus)

Project Details