Investigation of the fundamental roles of class Ib MHC molecules in immunity

  • Clements, Craig, (Primary Chief Investigator (PCI))
  • Brooks, Andrew G. (Chief Investigator (CI))

Project: Research

Project Description

Recognition of classical MHC class I molecules by CD8 T cells has long been known to represent an integral component of the adaptive immune response to pathogens. In contrast, the immunological roles of non-classical class I molecules are only just beginning to be understood. This study aims to determine the structure of several non-classical MHC molecules and their fundamental ligands using X-ray crystallography, and combine this structural data with biophysical data. Ultimately this proposal aims to provide an understanding of the function of these molecules in innate and adaptive immunity.
StatusFinished
Effective start/end date1/01/0731/12/11

Funding

  • Australian Research Council (ARC): AUD158,535.00
  • Australian Research Council (ARC): AUD574,465.00