Investigation of small molecule interactions with the human leukocyte antigen and their role in non-infectious disease

Illing, Patricia (Primary Chief Investigator (PCI))

Biochemistry & Molecular Biology

Project: Research

Status	Finished
Effective start/end date	1/01/14 → 31/12/17

Funding

National Health and Medical Research Council (NHMRC) (Australia): A$304,596.00

12 Article
2 Review Article

The allopurinol metabolite, oxypurinol, drives oligoclonal expansions of drug-reactive T cells in resolved hypersensitivity cases and drug-naïve healthy donors
Mifsud, N. A., Illing, P. T., Ho, R., Tuomisto, J. E., Fettke, H., Mullan, K. A., McCluskey, J., Rossjohn, J., Vivian, J., Reantragoon, R. & Purcell, A. W., Nov 2023, In: Allergy. 78, 11, p. 2980-2993 14 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

4 Citations (Scopus)
Carbamazepine Induces Focused T Cell Responses in Resolved Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Cases But Does Not Perturb the Immunopeptidome for T Cell Recognition
Mifsud, N. A., Illing, P. T., Lai, J. W., Fettke, H., Hensen, L., Huang, Z., Rossjohn, J., Vivian, J. P., Kwan, P. & Purcell, A. W., 12 Apr 2021, In: Frontiers in Immunology. 12, 20 p., 653710.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

15 Citations (Scopus)
CD8⁺ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph
Hensen, L., Illing, P. T., Bridie Clemens, E., Nguyen, T. H. O., Koutsakos, M., van de Sandt, C. E., Mifsud, N. A., Nguyen, A. T., Szeto, C., Chua, B. Y., Halim, H., Rizzetto, S., Luciani, F., Loh, L., Grant, E. J., Saunders, P. M., Brooks, A. G., Rockman, S., Kotsimbos, T. C. & Cheng, A. C. & 16 others, Richards, M., Westall, G. P., Wakim, L. M., Loudovaris, T., Mannering, S. I., Elliott, M., Tangye, S. G., Jackson, D. C., Flanagan, K. L., Rossjohn, J., Gras, S., Davies, J., Miller, A., Tong, S. Y. C., Purcell, A. W. & Kedzierska, K., 18 May 2021, In: Nature Communications. 12, 1, 20 p., 2931.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

28 Citations (Scopus)

Australian Synchrotron
Office of the Vice-Provost (Research and Research Infrastructure)
Facility/equipment: Facility

Investigation of small molecule interactions with the human leukocyte antigen and their role in non-infectious disease

Project Details

Funding

Research output

The allopurinol metabolite, oxypurinol, drives oligoclonal expansions of drug-reactive T cells in resolved hypersensitivity cases and drug-naïve healthy donors

Carbamazepine Induces Focused T Cell Responses in Resolved Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Cases But Does Not Perturb the Immunopeptidome for T Cell Recognition

CD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph

Equipment

Australian Synchrotron

CD8⁺ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph