Investigating the roles of non-coding RNAs in inflammatory signalling and cancer

Conos, Stephanie (Primary Chief Investigator (PCI))
Lawlor, Kathryn (Supervisor)

Hudson Institute - Centre for Innate Immunity and Infectious Disease

Project: Research

Status	Relinquished
Effective start/end date	5/08/19 → 11/11/22

Keywords

nuclear factor kappa-B (NF-KB),
inflammation
tumour necrosis factor (TNF)
RNA,
signalling

2 Article
1 Review Article

Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency
Hughes, S. A., Lin, M., Weir, A., Huang, B., Xiong, L., Chua, N. K., Pang, J., Santavanond, J. P., Tixeira, R., Doerflinger, M., Deng, Y., Yu, C. H., Silke, N., Conos, S. A., Frank, D., Simpson, D. S., Murphy, J. M., Lawlor, K. E., Pearson, J. S., Silke, J., & 10 othersPellegrini, M., Herold, M., Poon, I. K. H., Masters, S. L., Li, M., Tang, Q., Zhang, Y., Rashidi, M., Geng, L. & Vince, J. E., 1 Mar 2023, In: The EMBO Journal. 42, 5, 21 p.
Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway
Simpson, D. S., Pang, J., Weir, A., Kong, I. Y., Fritsch, M., Rashidi, M., Cooney, J. P., Davidson, K. C., Speir, M., Djajawi, T. M., Hughes, S., Mackiewicz, L., Dayton, M., Anderton, H., Doerflinger, M., Deng, Y., Huang, A. S., Conos, S. A., Tye, H., Chow, S. H., & 16 othersRahman, A., Norton, R. S., Naderer, T., Nicholson, S. E., Burgio, G., Man, S. M., Groom, J. R., Herold, M. J., Hawkins, E. D., Lawlor, K. E., Strasser, A., Silke, J., Pellegrini, M., Kashkar, H., Feltham, R. & Vince, J. E., 8 Mar 2022, In: Immunity. 55, 3, p. 423-441.e9 28 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

39 Citations (Scopus)
Targeting rip kinases in chronic inflammatory disease
Speir, M., Djajawi, T. M., Conos, S. A., Tye, H. & Lawlor, K. E., May 2021, In: Biomolecules. 11, 5, 22 p., 646.
Research output: Contribution to journal › Review Article › Research › peer-review

Open Access

17 Citations (Scopus)

Animal Research Platform (MARP)
Christine Findlay (Manager)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility
Bioinformatics Platform
Deanna Deveson (Manager)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility
FlowCore
Andrew Fryga (Manager)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility

Investigating the roles of non-coding RNAs in inflammatory signalling and cancer

Project Details

Keywords

Research output

Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

Targeting rip kinases in chronic inflammatory disease

Equipment

Animal Research Platform (MARP)

Bioinformatics Platform

FlowCore