Investigating the effects of cholesterol on the behaviour of non-lamellar liquid crystalline systems

  • Dong, Charlie, (Primary Chief Investigator (PCI))

Project: Research

Project Description

Cholesterol can reduce the lipid bilayer fluidity in lamellar liquid crystalline systems. As such, it is an essential component of cell membranes and in liposome formulations for drug delivery.Non-lamellar structured liquid crystalline systems also have a relevant role in biology, and have potential advantages over liposomes as drug delivery agents. This project investigates the effects of cholesterol on the internal structure and bilayer fluidity of non-lamellar liquid crystalline nanoparticles, hexosomes and cubosomes, and consequent impact on their drug encapsulation and release properties. The insight gained in this project helps to further engineer cubosomes and hexosomes as drug delivery agents.
StatusFinished
Effective start/end date1/07/1330/06/14

Funding

  • Australian Institute of Nuclear Science and Engineering (AINSE): AUD7,830.00