Investigating the dynamic nature of antibody stability

Project: Research

Project Details

Project Description

Monoclonal antibodies have transformed the study of biological processes and represent blockbuster therapeutics
for cancer and inflammation. Unfortunately, antibodies often display limited stability, which greatly hinders
development. We have recently identified mutations that render human antibodies resistant to aggregation, and
have determined high-resolution crystal structures to identify function. Intriguingly, our preliminary data indicates
that the mutations do not affect the native antibody structure, but rather influence dynamic states. We will utilize a
combination of mutagenesis, MD simulation and deuterium exchange to study antibody dynamics. Our work will
provide insights into the molecular mechanisms of antibody stability.
StatusFinished
Effective start/end date1/01/1630/12/18

Funding

  • Australian Research Council (ARC): AUD146,720.00