Insulin-like growth factor binding proteins: Structure and ligand interactions

  • Bach, Leon (Primary Chief Investigator (PCI))
  • Wallace, John (Chief Investigator (CI))
  • Yao, Shenggen (Chief Investigator (CI))

Project: Research

Project Details

Project Description

Insulin-like frowth factors are important for normal growth and development. Their actions are requlated by a family of IGF binding proteins. In order to understand the mechanism of this regulation, the aim of this project is to determine the 3-dimensional structure of 2 IGFBPs in complex with IGFs. This will lead to a comprehensive understanding of this interaction that promises to provide important basic knowledge as well as having major implications for biotechnology, agriculture and health.
Effective start/end date1/01/0431/12/07


  • Australian Research Council (ARC): AUD156,701.00