Improving on nature: diversifying glycopeptide antibiotics to kill the bacterial pathogen Staphylococcus aureus

Research output

Research output per year 2018 2018 2019 2020 2021 2023

• 18 Article
• 3 Review Article

Research output per year

Research output per year

Search results

• 2023

  Chemoselective Methionine Labelling of Recombinant Trastuzumab Shows High In Vitro and In Vivo Tumour Targeting

  Hashad, R., Jap, E., Casey, J. L., Ho, Y. T. C., Wright, A., Thalmann, C., Sleeman, M., Lupton, D. W., Hagemeyer, C. E., Cryle, M. J., Robert, R. & Alt, K., 21 Feb 2023, In: Chemistry - A European Journal. 29, 11, 7 p., e202202491.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  3 Citations (Scopus)
• 2022

  The Cytochrome P450 OxyA from the Kistamicin Biosynthesis Cyclization Cascade is Highly Sensitive to Oxidative Damage

  Greule, A., Izoré, T., Machell, D., Hansen, M. H., Schoppet, M., De Voss, J. J., Charkoudian, L. K., Schittenhelm, R. B., Harmer, J. R. & Cryle, M. J., 8 Apr 2022, In: Frontiers in Chemistry. 10, 18 p., 868240.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  7 Citations (Scopus)
• 2021

  Communication Breakdown: Dissecting the COM Interfaces between the Subunits of Nonribosomal Peptide Synthetases

  Fage, C. D., Kosol, S., Jenner, M., Öster, C., Gallo, A., Kaniusaite, M., Steinbach, R., Staniforth, M., Stavros, V. G., Marahiel, M. A., Cryle, M. J. & Lewandowski, J. R., 3 Sept 2021, In: ACS Catalysis. 11, 17, p. 10802-10813 12 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  15 Citations (Scopus)

• Staphylococcus aureus entanglement in self-assembling β-peptide nanofibres decorated with vancomycin

  Payne, J. A. E., Kulkarni, K., Izore, T., Fulcher, A. J., Peleg, A. Y., Aguilar, M. I., Cryle, M. J. & Del Borgo, M. P., 7 May 2021, In: Nanoscale Advances. 3, 9, p. 2607-2616 10 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  8 Citations (Scopus)

• Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity

  Izoré, T., Candace Ho, Y. T., Kaczmarski, J. A., Gavriilidou, A., Chow, K. H., Steer, D. L., Goode, R. J. A., Schittenhelm, R. B., Tailhades, J., Tosin, M., Challis, G. L., Krenske, E. H., Ziemert, N., Jackson, C. J. & Cryle, M. J., Dec 2021, In: Nature Communications. 12, 1, 14 p., 2511.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  49 Citations (Scopus)

• Understanding the early stages of peptide formation during the biosynthesis of teicoplanin and related glycopeptide antibiotics

  Kaniusaite, M., Tailhades, J., Kittilä, T., Fage, C. D., Goode, R. J. A., Schittenhelm, R. B. & Cryle, M. J., Jan 2021, In: The FEBS Journal. 288, 2, p. 507-529 22 p.

  Research output: Contribution to journal › Article › Research › peer-review
  16 Citations (Scopus)
• 2020

  A Chemoenzymatic Approach to the Synthesis of Glycopeptide Antibiotic Analogues

  Tailhades, J., Zhao, Y., Ho, Y. T. C., Greule, A., Ahmed, I., Schoppet, M., Kulkarni, K., Goode, R. J. A., Schittenhelm, R. B., De Voss, J. J. & Cryle, M. J., 26 Jun 2020, In: Angewandte Chemie - International Edition. 59, 27, p. 10899-10903 5 p.

  Research output: Contribution to journal › Article › Research › peer-review
  28 Citations (Scopus)

• Exploring modular reengineering strategies to redesign the teicoplanin non-ribosomal peptide synthetase

  Kaniusaite, M., Goode, R. J. A., Tailhades, J., Schittenhelm, R. B. & Cryle, M. J., 21 Sept 2020, In: Chemical Science. 11, 35, p. 9443-9458 16 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  19 Citations (Scopus)

• Exploring the Tetracyclization of Teicoplanin Precursor Peptides through Chemoenzymatic Synthesis

  Zhao, Y., Goode, R. J. A., Schittenhelm, R. B., Tailhades, J. & Cryle, M. J., 7 Feb 2020, In: The Journal of Organic Chemistry. 85, 3, p. 1537-1547 11 p.

  Research output: Contribution to journal › Article › Research › peer-review
  17 Citations (Scopus)

• Redesign of Substrate Selection in Glycopeptide Antibiotic Biosynthesis Enables Effective Formation of Alternate Peptide Backbones

  Kaniusaite, M., Kittilä, T., Goode, R. J. A., Schittenhelm, R. B. & Cryle, M. J., 18 Sept 2020, In: ACS Chemical Biology. 15, 9, p. 2444-2455 12 p.

  Research output: Contribution to journal › Article › Research › peer-review
  8 Citations (Scopus)
• 2019

  A proof-reading mechanism for non-proteinogenic amino acid incorporation into glycopeptide antibiotics

  Kaniusaite, M., Tailhades, J., Marschall, E. A., Goode, R. J. A., Schittenhelm, R. B. & Cryle, M. J., 29 Aug 2019, In: Chemical Science. 10, 41, p. 9466-9482 17 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  44 Citations (Scopus)

• Drosophila melanogaster nonribosomal peptide synthetase Ebony encodes an atypical condensation domain

  Izoré, T., Tailhades, J., Hansen, M. H., Kaczmarski, J. A., Jackson, C. J. & Cryle, M. J., 19 Feb 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 2913-2918 6 p.

  Research output: Contribution to journal › Article › Research › peer-review
  22 Citations (Scopus)

• Enzymatic Cascade to Evaluate the Tricyclization of Glycopeptide Antibiotic Precursor Peptides as a Prequel to Biosynthetic Redesign

  Tailhades, J., Zhao, Y., Schoppet, M., Greule, A., Goode, R. J. A., Schittenhelm, R. B., De Voss, J. J. & Cryle, M. J., 1 Nov 2019, In: Organic Letters. 21, 21, p. 8635-8640 6 p.

  Research output: Contribution to journal › Article › Research › peer-review
  18 Citations (Scopus)

• Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics

  Greule, A., Izoré, T., Iftime, D., Tailhades, J., Schoppet, M., Zhao, Y., Peschke, M., Ahmed, I., Kulik, A., Adamek, M., Goode, R. J. A., Schittenhelm, R. B., Kaczmarski, J. A., Jackson, C. J., Ziemert, N., Krenske, E. H., De Voss, J. J., Stegmann, E. & Cryle, M. J., 13 Jun 2019, In: Nature Communications. 10, 1, 15 p., 2613.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  42 Citations (Scopus)

• The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis

  Schoppet, M., Peschke, M., Kirchberg, A., Wiebach, V., Süssmuth, R. D., Stegmann, E. & Cryle, M. J., 1 Jan 2019, In: Chemical Science. 10, 1, p. 118-133 16 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  21 Citations (Scopus)

• The Diiron Monooxygenase CmlA from Chloramphenicol Biosynthesis Allows Reconstitution of β-Hydroxylation during Glycopeptide Antibiotic Biosynthesis

  Kaniusaite, M., Goode, R. J. A., Schittenhelm, R. B., Makris, T. M. & Cryle, M. J., 20 Dec 2019, In: ACS Chemical Biology. 14, 12, 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  15 Citations (Scopus)
• 2018

  Investigating Cytochrome P450 specificity during glycopeptide antibiotic biosynthesis through a homologue hybridization approach

  Brieke, C., Tarnawski, M., Greule, A. & Cryle, M. J., 1 Aug 2018, In: Journal of Inorganic Biochemistry. 185, p. 43-51 9 p.

  Research output: Contribution to journal › Article › Research › peer-review
  6 Citations (Scopus)

• Precursor Manipulation in Glycopeptide Antibiotic Biosynthesis: Are β-Amino Acids Compatible with the Oxidative Cyclization Cascade?

  Schoppet, M., Tailhades, J., Kulkarni, K. & Cryle, M. J., 6 Jul 2018, In: The Journal of Organic Chemistry. 83, 13, p. 7206-7214 9 p.

  Research output: Contribution to journal › Article › Research › peer-review
  13 Citations (Scopus)