The present theory driving the pathogenesis of Idiopathic Pulmonary Fibrosis (IPF) is related to damage to the alveolar epithelium and endothelium. There are several mechanisms that have been described in the ongoing damage to epithelium and endothelium in IPF. These include: apoptosis; ER stress; mitochondrial dysfunction; telomere shortening; endothelial mesenchymal transition; DNA damage; autophagy and cellular senescence. It is uncertain whether all processes mentioned are present in every patient with IPF. In addition, we do not have any insights into the spatial relationship between the pathogenic processes and molecules expressed in the lung. The questions are: is each of the mechanisms in the pathogenesis of IPF present in every patient; and can we relate the spatial appearance of alveolar and endothelial damage to distinct molecules within the lung? In this project we will apply a multimodal hyperspectral imaging approach to these questions combining Focal Plane Array infrared imaging, Raman hyperspectral mapping and Atomic Force Microscopy Infrared (AFM IR) imaging on the same tissue samples.
|Effective start/end date||1/09/18 → 31/12/18|
- Institute for Respiratory Health: AUD67,826.00