Project Details
Project Description
The goal of this project is to develop a therapy that rejuvenates mitochondria during early embryo
development so that dysfunctional mitochondria within an egg are not perpetuated into offspring
tissues. Specifically, we will test whether mitochondria targeted compounds (BGP-15, SS-31 and/or
MitoQ) that stabilise the mitochondrial cristae of the egg could be used to promote preferential
biogenesis of healthy mitochondria and thereby minimise transmission of defective mitochondria to the
embryo after fertilisation.
development so that dysfunctional mitochondria within an egg are not perpetuated into offspring
tissues. Specifically, we will test whether mitochondria targeted compounds (BGP-15, SS-31 and/or
MitoQ) that stabilise the mitochondrial cristae of the egg could be used to promote preferential
biogenesis of healthy mitochondria and thereby minimise transmission of defective mitochondria to the
embryo after fertilisation.
| Status | Finished |
|---|---|
| Effective start/end date | 1/10/21 → 31/12/21 |