How to build the head: A molecular mechanistic insight

This project aims to gain an insight into the functional output of the gene regulatory network that is anchored by a
key transcription factor to choreograph head development. Genome-wide sequencing technologies are employed
to identify the ensemble of genes that are regulated by Lhx1. By a combination of bioinformatics analysis and a
system biology approach, we will build a model of the network of the interacting genes for head development. We
will characterise the function of selected components of this network to refine its architecture and define the
dynamics of the network. This study is the precedent of a systematic investigation of a gene regulatory network for
the development of a major body part of the embryo.