Host-directed therapy for malaria: host cell signalome as a target

  • Wilson, Danny W (Primary Chief Investigator (PCI))
  • Adderley, Jack (Chief Investigator (CI))
  • Farr, Graham (Chief Investigator (CI))
  • Egan, Elizabeth (Chief Investigator (CI))
  • Tobin, Andrew B. (Chief Investigator (CI))

Project: Research

Project Details

Project Description

[from current draft application:]
Malaria parasites kill 450,000 children a year and impact on the economic development of communities. Spreading drug resistant malaria parasites within Australia’s South-East Asian neighbours creates an urgent and unmet need for new drug treatments. We will characterise host signals required for parasite survival in immature erythrocytes and identify host-directed, ready to develop, resistance-proofed drugs to kill malaria parasites.
[note added by GF:]
My role will be to lead the development of network analysis algorithms to assist in the development of new drugs for malaria.
Short titleHost-directed therapy for malaria
StatusActive
Effective start/end date1/01/2131/12/23

Funding

  • National Health and Medical Research Council (NHMRC) (Australia): AUD898,043.20

Keywords

  • malaria
  • plasmodium
  • antimalarial
  • host/pathogen interaction
  • kinase inhibitors
  • network analysis