Project Details
Project Description
[from current draft application:]
Malaria parasites kill 450,000 children a year and impact on the economic development of communities. Spreading drug resistant malaria parasites within Australia’s South-East Asian neighbours creates an urgent and unmet need for new drug treatments. We will characterise host signals required for parasite survival in immature erythrocytes and identify host-directed, ready to develop, resistance-proofed drugs to kill malaria parasites.
[note added by GF:]
My role will be to lead the development of network analysis algorithms to assist in the development of new drugs for malaria.
Malaria parasites kill 450,000 children a year and impact on the economic development of communities. Spreading drug resistant malaria parasites within Australia’s South-East Asian neighbours creates an urgent and unmet need for new drug treatments. We will characterise host signals required for parasite survival in immature erythrocytes and identify host-directed, ready to develop, resistance-proofed drugs to kill malaria parasites.
[note added by GF:]
My role will be to lead the development of network analysis algorithms to assist in the development of new drugs for malaria.
| Short title | Host-directed therapy for malaria |
|---|---|
| Status | Finished |
| Effective start/end date | 1/01/21 → 31/12/23 |
Funding
- National Health and Medical Research Council (NHMRC) (Australia): A$898,043.20
Keywords
- malaria
- plasmodium
- antimalarial
- host/pathogen interaction
- kinase inhibitors
- network analysis