Gut Lung Axis in Cystic Fibrosis (GLAX-CF)

Description of Research Project: The Gut Lung Axis in Cystic Fibrosis study explores the evolution of the gastrointestinal and lower airway microbiota and metabolome and their relationship to systemic and airway inflammation and clinical outcome measures in infants with cystic fibrosis. 16S rRNA gene sequencing, shotgun metagenomics and metabolomic analyses will be performed on serial stool, plasm and bronchoalveolar lavage fluid samples from 35 infants with CF.

Breakdown of responsibilities: Murdoch Children’s Research Institute is responsible for recruitment and collection of biological samples and clinical data. Monash University is responsible for 16S rRNA gene sequencing, shotgun metagenomics and metabolomic analyses as agreed, and for bioinformatic analysis of these findings together with clinical metadata. Both parties will be responsible for data interpretation and presentation for publication.