During absorption from the gastrointestinal tract, drug molecules stimulate feedback mechanisms in intestinal absorptive cells which increase (upregulate) the levels of expression of a range of proteins and enzymes that mediate detoxification. This provides a protective role against exposure to unintended toxins, but also constitutes a formidable barrier to the delivery of orally administered drugs. The current proposal will map the chemical interactions that occur between drug molecules, transport proteins and receptors in the nucleus that together promote upregulation of this barrier to drug absorption. Successful project completion will significantly improve our understanding of the mechanisms of drug absorption and transport.
|Effective start/end date||5/01/09 → 30/06/12|
- Australian Research Council (ARC): AUD360,000.00