GGN as a regulator of DNA double strand break repair and genome integrity

  • O'Bryan, Moira (Primary Chief Investigator (PCI))
  • Jamsai, Duangporn (Chief Investigator (CI))
  • Ormandy, Christopher J. (Chief Investigator (CI))
  • Handel, Mary Ann (Partner Investigator (PI))

Project: Research

Project Details

Project Description

Faithful repair of DNA damage is critical for the maintenance of genome integrity in all living organisms.
Defects in the repair process can lead to cancer, infertility, birth defects and many genome instability
syndromes. The repair process is achieved by a complex orchestration of checkpoint and DNA repair
proteins. Despite their vital role, the precise mechanisms of how these proteins coordinate the repair is
largely unknown. This project will define the function of gametogenetin (GGN), a previously unknown
component of the DNA damage repair pathway. The research outcomes will present important contributions
to our understanding of DNA repair biology in development and disease prevention and ultimately will lead to
better public health.
StatusFinished
Effective start/end date4/01/1131/12/13

Funding

  • Australian Research Council (ARC): AUD360,000.00
  • Australian Research Council (ARC)