Genetic regulation of testis development in the chicken embryo
White, Stefan (Primary Chief Investigator (PCI))
Sinclair, Andrew (Chief Investigator (CI))
Smith, Craig (Chief Investigator (CI))
Testis formation during embryonic life provides an excellent model for studying the genetic control of development. The aim of this project is to enhance our understanding of testis development, using a unique approach that exploits the chicken embryo as a model system. We will use innovative methods to study a key gene, DMRT1, recently shown by us to be required for proper testis development in the chicken. This project it will make a substantial contribution to our understanding of sex determination and organ development. The project will have application to the poultry industry (sex ratio manipulation) and to human health (understanding gonadal disorders). It will further consolidate Australia's position as a world leader in this field.
Lambeth, L. S., Morris, K., Ayers, K. L., Wise, T. G., O'Neil, T., Wilson, S., Cao, Y., Sinclair, A. H., Cutting, A. D., Doran, T. J. & Smith, C. A., Mar 2016, In: Endocrinology.157, 3, p. 1258-127518 p.
Research output: Contribution to journal › Article › Research › peer-review