Genetic and Molecular basis of appendicular muscle formation

  • Currie, Peter (Primary Chief Investigator (PCI))
  • Hollway, Georgina (Partner Investigator (PI))

Project: Research

Project Details

Project Description

Limbs muscles provide the major locomotor force for most land based tetrapods, including ourselves, yet we
understand little of how these muscle cells are specified in the early embryo. Zebrafish fin muscles are
generated by similar processes to those controlling tetrapod limb muscle formation. This study aims to
harness the power of zebrafish genetics to describe how individual genes act to control formation of fin
muscle progenitors. We have identified novel genetic regulators of fin myogenesis and in this application
design experiments to understand how they act to regulate fin muscle formation. Identifying the genes that
control fin muscle formation helps us understand how evolution acts to generate different locomotor
strategies.
StatusFinished
Effective start/end date4/01/111/06/14

Funding

  • Australian Research Council (ARC): AUD280,000.00