G Protein-Coupled Receptor Context-Specific Biased Agonism to Treat Ischaemic Heart Disease

May, Lauren (Primary Chief Investigator (PCI))

Drug Discovery Biology

Project: Research

7 Review Article
3 Article

3 results

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2022

Examining the Role of the Linker in Bitopic N⁶-Substituted Adenosine Derivatives Acting as Biased Adenosine A₁Receptor Agonists
Awalt, J. K., Nguyen, A. T. N., Fyfe, T. J., Thai, B. S., White, P. J., Christopoulos, A., Jörg, M., May, L. T. & Scammells, P. J., 21 Jun 2022, In: Journal of Medicinal Chemistry. 65, 13, p. 9076–9095 20 p.
Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)
2019

Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology
Sengmany, K., Hellyer, S. D., Albold, S., Wang, T., Conn, P. J., May, L. T., Christopoulos, A., Leach, K. & Gregory, K. J., 1 May 2019, In: Neuropharmacology. 149, p. 83-96 14 p.
Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)
2018

Structure of the adenosine-bound human adenosine A₁ receptor-G_i complex
Draper-Joyce, C. J., Khoshouei, M., Thal, D. M., Liang, Y. L., Nguyen, A. T. N., Furness, S. G. B., Venugopal, H., Baltos, J. A., Plitzko, J. M., Danev, R., Baumeister, W., May, L. T., Wootten, D., Sexton, P. M., Glukhova, A. & Christopoulos, A., 20 Jun 2018, In: Nature. 558, 7711, p. 559-565 7 p.
Research output: Contribution to journal › Article › Research › peer-review

243 Citations (Scopus)