Frizzled pharmacology and signal transduction

The Frizzled family of receptors is important for embryonic development and is involved in a variety of diseases, such as cancer, neuropathies and developmental defects. This project will characterize Frizzled pharmacology by receptor binding and examine dose-response-relationships and intracellular signal transduction mechanisms. Findings will be applied to clinically relevant systems such as Alzheimer's disease and the sensory nervous system to provide opportunities for pharmacological intervention in the treatment of neurodegenerative diseases and neuropathic pain.