Project Details
Project Description
In patients with atypical femur fractures, we aim to:
1. Identify variants in previously unidentified genes that confer an increased risk of atypical femur fractures with antiresorptive therapy and their function.
2. Determine if genetic variants are present in exons related to monogenetic bone diseases, including those we have previously associated with AFF and examine their function.
3. Quantify abnormalities in bone remodeling, tissue mineral density and bone microstructure associated with atypical femur fractures.
1. Identify variants in previously unidentified genes that confer an increased risk of atypical femur fractures with antiresorptive therapy and their function.
2. Determine if genetic variants are present in exons related to monogenetic bone diseases, including those we have previously associated with AFF and examine their function.
3. Quantify abnormalities in bone remodeling, tissue mineral density and bone microstructure associated with atypical femur fractures.
Short title | TrAFFiC Study of Atypical Femur Fractures |
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Acronym | TrAFFiC |
Status | Active |
Effective start/end date | 1/01/18 → 31/12/22 |
Funding
- National Health and Medical Research Council (NHMRC) (Australia): AUD1,053,094.00