Factors involved in release of cytochrome c from mitochondria during apoptosis

Project: Research

Project Description

Mitochondria are energy-producing organelles that activate cell death by selective release of constituents, notably cytochrome c, which participate in death-signalling cascades. I aim to probe such mitochondrial release mechanisms in intact cells, by focussing on features of translocated proteins relevant to release. Cultured mouse cells lacking cytochrome c are uniquely suited to these studies. A series of cytochrome c derivatives will be engineered in elongated or aggregated forms and their release studied (including interactions with putative release machinery components) following death-signal activation. The project will elucidate a central mechanism in the cell death process, highly significant in many biological contexts.
StatusFinished
Effective start/end date1/01/0231/12/04

Funding

  • Australian Research Council (ARC): AUD181,400.00
  • Monash University