Exploring the anti-apoptotic and apoptosis-unrelated functions of MCL-1 during embryonic and blood cell development to advance MCL-1 inhibitors in clinical trials for cancer

  • Brinkmann, Kerstin (Primary Chief Investigator (PCI))
  • McArthur, Kate (Chief Investigator (CI))

Project: Research

Project Details

Project Description

In a healthy organism damaged or autoreactive cells kill themselves by a controlled cell death program, called apoptosis. Pro-survival proteins (e.g. MCL-1) block apoptosis, and their enhanced expression causes cancer. Some pro-survival inhibitory drugs (e.g. Venetoclax) are effective and well tolerated, whereas the highly effective MCL-1 inhibitors cause intolerable side effects in clinical trials. This project aims to determine the differences of these proteins to improve cancer therapy.
Short titleExploring the non-apoptotic functions of Mcl-1
Effective start/end date1/01/2331/12/25