Exploring metabotropic glutamate receptor 5 bias, allostery and heteromers

This Project aims to provide novel mechanistic and structural insights into metabotropic glutamate receptor 5 (mGlu5) function. The mGlu5 is an essential regulator of neurotransmission and higher order brain functions including learning and memory. This Project expects to expand our knowledge of these fundamental biological processes engaged by mGlu5 through exploration of three novel paradigms of receptor activity: allostery, bias and heteromerisation. Expected outcomes also include generation of new pharmacological tools through interdisciplinary collaborative research between multiple institutions. There is potential for economic benefit through commercialisation of new tools and facilitation of novel drug discovery.