Expanding the molecular tool set for structural studies of proteins and their complexes

  • Graham, Bimbil, (Primary Chief Investigator (PCI))

Project: Research

Project Description

Many applications in medical science and drug development depend on our ability to determine the 3D structures of proteins, protein assemblies and protein-ligand complexes. This project will develop novel lanthanide-binding tags and crosslinking agents that can be coupled to unnatural amino acids introduced into proteins with advanced protein chemistry techniques. These new tools will facilitate the collection of structure restraints by NMR, EPR and mass spectrometry, which are needed to generate accurate models of proteins and their complexes with other molecules. Major beneficial outcome will include an increase in the number of protein targets amenable to rational drug design and improved methods for generating new drug leads.
StatusFinished
Effective start/end date1/01/1431/12/17

Funding

  • Australian Research Council (ARC): AUD555,320.00
  • Australian Research Council (ARC): AUD188,504.00