Examining the role of TcdB in extraintestinal damage during Clostridium difficile infection using bezlotoxumab.

Project: Research

Project Description

The specific aims of this project are:

1. To determine if TcdB acts directly on the thymus to cause atrophy, and if bezlotoxumab-mediated neutralisation prevents this damage from occurring.

2. To determine if the administration of bezlotoxumab during infection prevents thymic damage from occurring, and if this effect is linked to intestinal damage.
Effective start/end date1/07/1830/06/20