Evolution of the dermomyotome in vertebrates

Project: Research

Project Details

Project Description

All amniote muscles, except that of the head, derive from a transient embryonic structure termed the
dermomyotome. The formation of muscle from the dermomyotome of amniotes uses a highly conserved
mechanism that distinct from that deployed by bony fish and amphibians. How the dermomyotome evolved to
generate the distinct types of locomotor systems we see deployed through out the vertebrate phylogeny remains
unresolved. In a very surprising set of new findings we have recently determined amniote-like muscle
development in one of the most basal extant gnathostomes, the elephant shark (C. milii) but not in lamprey and
or paddlefish embryos. This proposal seeks to examine the molecular basis of these striking evolutionary
changes.
StatusFinished
Effective start/end date1/01/1631/12/18

Funding

  • Australian Research Council (ARC): AUD399,100.00
  • Monash University