Research output per year
Research output per year
Project Details
Project Description
AB5 toxins are comprised of one catalytic A subunit that disrupts distinct essential cellular processes within the cell and receptor binding, pentameric B subunit that enables the toxin to target certain cell types. How these toxins evolved to infect human hosts are poorly understood. The aims of this proposal are to investigate how B pentamer evolved by comparing the structure and function of two related toxins and performing directed evolution on the B-pentamer. The outcomes of this proposal will aid in understanding the mechanism AB5 toxins have evolved to invade human hosts with potential to develop novel antimicrobials
| Status | Finished |
|---|---|
| Effective start/end date | 4/01/10 → 31/12/12 |
Funding
- Australian Research Council (ARC): A$390,000.00
- University of Adelaide
Research output
- 1 Article
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Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins
Littler, D. R., Ang, S. Y., Moriel, D. G., Kocan, M., Kleifeld, O., Johnson, M. D., Tran, M. T., Paton, A. W., Paton, J. C., Summers, R. J., Schembri, M. A., Rossjohn, J. & Beddoe, T., 8 Sept 2017, In: Journal of Biological Chemistry. 292, 36, p. 15143-15158 16 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile22 Citations (Scopus)
Equipment
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Australian Synchrotron
Office of the Vice-Provost (Research and Research Infrastructure)Facility/equipment: Facility