Enhancing anti-parasitic drug discovery with metabolomics

Research output

Research output per year 2019 2019 2020 2021 2022 2022

• 11 Article
• 3 Review Article

Research output per year

Research output per year

Search results

• 2022

  A new mass spectral library for high-coverage and reproducible analysis of the Plasmodium falciparum-infected red blood cell proteome

  Siddiqui, G., De Paoli, A., MacRaild, C. A., Sexton, A. E., Boulet, C., Shah, A. D., Batty, M. B., Schittenhelm, R. B., Carvalho, T. G. & Creek, D. J., 7 Mar 2022, In: GigaScience. 11, 17 p., giac008.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  14 Citations (Scopus)

• Current and emerging target identification methods for novel antimalarials

  Challis, M. P., Devine, S. M. & Creek, D. J., Dec 2022, In: International Journal for Parasitology: Drugs and Drug Resistance. 20, p. 135-144 10 p.

  Research output: Contribution to journal › Review Article › Research › peer-review

  Open Access
  10 Citations (Scopus)

• Lipidomics profiles in hepatocytes from nonalcoholic steatohepatitis patients differ markedly from in vitro-induced steatotic hepatocytes

  Kralj, T., Khatri, R., Brouwer, K. R., Brouwer, K. L. R. & Creek, D. J., Jun 2022, In: FEBS Letters. 596, 11, p. 1445-1452 8 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  2 Citations (Scopus)

• Peroxide Antimalarial Drugs Target Redox Homeostasis in Plasmodium falciparum Infected Red Blood Cells

  Siddiqui, G., Giannangelo, C., De Paoli, A., Schuh, A. K., Heimsch, K. C., Anderson, D., Brown, T. G., Macraild, C. A., Wu, J., Wang, X., Dong, Y., Vennerstrom, J. L., Becker, K. & Creek, D. J., 14 Jan 2022, In: ACS Infectious Diseases. 8, 1, p. 210-226 17 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  30 Citations (Scopus)

• Targeting malaria parasites with novel derivatives of azithromycin

  Burns, A. L., Sleebs, B. E., Gancheva, M., McLean, K. T., Siddiqui, G., Venter, H., Beeson, J. G., O’Handley, R., Creek, D. J., Ma, S., Frölich, S., Goodman, C. D., McFadden, G. I. & Wilson, D. W., 30 Nov 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 16 p., 1063407.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  4 Citations (Scopus)
• 2021

  Analytical and Omics-Based Advances in the Study of Drug-Induced Liver Injury

  Kralj, T., Brouwer, K. L. R. & Creek, D. J., Sept 2021, In: Toxicological Sciences. 183, 1, p. 1-13 13 p.

  Research output: Contribution to journal › Review Article › Research › peer-review
  19 Citations (Scopus)

• The novel bis-1,2,4-Triazine MIPS-0004373 demonstrates rapid and potent activity against all blood stages of the malaria parasite

  Ellis, K. M., Lucantoni, L., Chavchich, M., Abraham, M., De Paoli, A., Luth, M. R., Zeeman, A. M., Delves, M. J., Terán, F. S. R., Straschil, U., Baum, J., Kocken, C. H. M., Ralph, S. A., Winzeler, E. A., Avery, V. M., Edstein, M. D., Baell, J. B. & Creek, D. J., Oct 2021, In: Antimicrobial Agents and Chemotherapy. 65, 11, 18 p., e00311-21.

  Research output: Contribution to journal › Article › Research › peer-review
  7 Citations (Scopus)

• β-Adrenoceptor regulation of metabolism in U937 derived macrophages

  Peterson, A. L., Siddiqui, G., Sloan, E. K. & Creek, D. J., 1 Aug 2021, In: Molecular Omics. 17, 4, p. 583-595 13 p.

  Research output: Contribution to journal › Article › Research › peer-review
  7 Citations (Scopus)
• 2020

  Multi-omic characterization of the mode of action of a potent new antimalarial compound, JPC-3210, against Plasmodium falciparum

  Birrell, G. W., Challis, M. P., de Paoli, A., Anderson, D., Devine, S. M., Heffernan, G. D., Jacobus, D. P., Edstein, M. D., Siddiqui, G. & Creek, D. J., 1 Feb 2020, In: Molecular & Cellular Proteomics. 19, 2, p. 308-325 18 p.

  Research output: Contribution to journal › Article › Research › peer-review
  26 Citations (Scopus)

• Retargeting azithromycin analogues to have dual-modality antimalarial activity

  Burns, A. L., Sleebs, B. E., Siddiqui, G., De Paoli, A. E., Anderson, D., Liffner, B., Harvey, R., Beeson, J. G., Creek, D. J., Goodman, C. D., McFadden, G. I. & Wilson, D. W., 29 Sept 2020, In: BMC Biology. 18, 1, 23 p., 133.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  15 Citations (Scopus)

• System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion

  Giannangelo, C., Siddiqui, G., de Paoli, A., Anderson, B. M., Edgington-Mitchell, L. E., Charman, S. A. & Creek, D. J., 26 Jun 2020, In: PLoS Pathogens. 16, 6, 32 p., e1008485.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  22 Citations (Scopus)
• 2019

  Ozonide Antimalarial Activity in the Context of Artemisinin-Resistant Malaria

  Giannangelo, C., Fowkes, F. J. I., Simpson, J. A., Charman, S. A. & Creek, D. J., 1 Jul 2019, In: Trends in Parasitology. 35, 7, p. 529-543 15 p.

  Research output: Contribution to journal › Review Article › Research › peer-review

  Open Access

  File
  44 Citations (Scopus)

• Ozonide Antimalarials Alkylate Heme in the Malaria Parasite Plasmodium falciparum

  Giannangelo, C., Anderson, D., Wang, X., Vennerstrom, J. L., Charman, S. A. & Creek, D. J., 17 Oct 2019, In: ACS Infectious Diseases. 5, 12, p. 2076-2086 11 p.

  Research output: Contribution to journal › Article › Research › peer-review
  17 Citations (Scopus)

• The Development Process for Discovery and Clinical Advancement of Modern Antimalarials

  Ashton, T. D., Devine, S., Mohrle, J., Laleu, B., Burrows, J. N., Charman, S., Creek, D. & Sleebs, B. E., 6 Aug 2019, In: Journal of Medicinal Chemistry. 62, 23, p. 10526-10562 37 p.

  Research output: Contribution to journal › Article › Research › peer-review
  60 Citations (Scopus)