Engendering biased signalling at the human calcium sensing receptor (CaSR) to correct pathophysiology

Leach, Katie (Primary Chief Investigator (PCI))
Conigrave, Arthur (Chief Investigator (CI))
Mason, Rebecca (Chief Investigator (CI))

University of Sydney

Project: Research

3 Article
1 Review Article

3 results

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2020

Negative allosteric modulators of the human calcium-sensing receptor bind to overlapping and distinct sites within the 7-transmembrane domain
Josephs, T. M., Keller, A. N., Khajehali, E., DeBono, A., Langmead, C. J., Conigrave, A. D., Capuano, B., Kufareva, I., Gregory, K. J. & Leach, K., Apr 2020, In: British Journal of Pharmacology. 177, 8, p. 1917-1930 14 p.
Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)
2019

L-Amino Acids Promote Calcitonin Release via a Calcium-Sensing Receptor: G_q/11-Mediated Pathway in Human C-Cells
Mun, H. C., Leach, K. M. & Conigrave, A. D., 1 Jan 2019, In: Endocrinology. 160, 7, p. 1590-1599 10 p.
Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)
2018

Dual action calcium-sensing receptor modulator unmasks novel mode-switching mechanism
Gregory, K., Kufareva, I., Keller, A. N., Khajehali, E., Mun, H., Goolam, M. A., Mason, R. S., Capuano, B., Conigrave, A., Christopoulos, A. & Leach, K., 12 Sep 2018, In: ACS Pharmacology & Translational Science. 1, 2, p. 96-109 14 p.
Research output: Contribution to journal › Article › Research › peer-review

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12 Citations (Scopus)